{"id":26964,"date":"2026-09-27T20:02:12","date_gmt":"2026-09-27T18:02:12","guid":{"rendered":"https:\/\/www.itspy.cz\/thesis\/use-of-predictive-models-in-patients-with-salivary-glandcarcinomas-in-the-czech-salivary-gland-database-application\/"},"modified":"2026-10-23T13:46:19","modified_gmt":"2026-10-23T11:46:19","slug":"use-of-predictive-models-in-patients-with-salivary-glandcarcinomas-in-the-czech-salivary-gland-database-application","status":"publish","type":"thesis","link":"https:\/\/www.itspy.cz\/en\/thesis\/use-of-predictive-models-in-patients-with-salivary-glandcarcinomas-in-the-czech-salivary-gland-database-application\/","title":{"rendered":"Use of predictive models in patients with salivary gland\ncarcinomas in the Czech Salivary Gland Database application"},"content":{"rendered":"<p>Salivary gland carcinomas are rare, heterogeneous<br \/>\n    malignancies that complicate prognostic stratification.<br \/>\n    This thesis documents the transformation of the Czech<br \/>\n    Salivary Gland Database from a retrospective repository<br \/>\n    into a dynamic clinical decision support system. The<br \/>\n    system uses a Python-based sidecar architecture<br \/>\n    integrated with an offline Electron\/React\/SQLite stack<br \/>\n    to ensure GDPR compliance and data sovereignty at the<br \/>\n    workstation level.<\/p>\n<p>    We implemented two predictive paradigms: a<br \/>\n    semi-parametric Cox Proportional Hazards baseline and a<br \/>\n    non-parametric Random Survival Forest. Validation on<br \/>\n    N=122 patients via the .632 bootstrap estimator yielded<br \/>\n    a concordance index of 0.814 for the Random Survival<br \/>\n    Forest, although overlapping confidence intervals<br \/>\n    reflect the constraints of the limited sample size. The<br \/>\n    application, featuring an explainability layer for<br \/>\n    clinical trust, is deployed at Motol University<br \/>\n    Hospital to assist with individualized treatment<br \/>\n    planning.<\/p>\n","protected":false},"featured_media":26692,"template":"","meta":{"_acf_changed":false,"_links_to":"","_links_to_target":""},"university":[169,167],"thesis-year":[466],"class_list":["post-26964","thesis","type-thesis","status-publish","has-post-thumbnail","hentry","thesis-year-466"],"acf":{"autor":"Vojt\u011bch Jel\u00ednek","portret":"","vedouci":"Ing. Petr Br\u016fha"},"_links":{"self":[{"href":"https:\/\/www.itspy.cz\/en\/wp-json\/wp\/v2\/thesis\/26964","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.itspy.cz\/en\/wp-json\/wp\/v2\/thesis"}],"about":[{"href":"https:\/\/www.itspy.cz\/en\/wp-json\/wp\/v2\/types\/thesis"}],"version-history":[{"count":1,"href":"https:\/\/www.itspy.cz\/en\/wp-json\/wp\/v2\/thesis\/26964\/revisions"}],"predecessor-version":[{"id":27019,"href":"https:\/\/www.itspy.cz\/en\/wp-json\/wp\/v2\/thesis\/26964\/revisions\/27019"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.itspy.cz\/en\/wp-json\/wp\/v2\/media\/26692"}],"wp:attachment":[{"href":"https:\/\/www.itspy.cz\/en\/wp-json\/wp\/v2\/media?parent=26964"}],"wp:term":[{"taxonomy":"university","embeddable":true,"href":"https:\/\/www.itspy.cz\/en\/wp-json\/wp\/v2\/university?post=26964"},{"taxonomy":"thesis-year","embeddable":true,"href":"https:\/\/www.itspy.cz\/en\/wp-json\/wp\/v2\/thesis-year?post=26964"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}